CURRICULUM   VITAE

Name:                                    Tom C. Tsang
Degree:                                  Ph.D.
Place and Date of Birth:     Taiwan, China, May 3, 1964
Citizenship:                         USA (Naturalized 1984).

EDUCATION:

1987-1994       Doctor of Philosophy
Microbiology and Immunology (minor in Cancer Biology)
University of Arizona,
Tucson, Arizona, USA.

1982-1985       Bachelor of Arts,Biochemistry
University of Arizona,
Tucson, Arizona, USA.

PAST EMPLOYMENT:

Academia:

6/2008-2017       Associate Investigator,
Cancer Biology and Genetics Program,
Arizona Cancer Center
University of Arizona
Tucson, Arizona, USA.

10/2004-9/2008  Research Assistant Professor,
Dept. of Immunobiology
College of Medicine
University of Arizona, USA

            8/1997-10/2004  Assistant Research Scientist,
Gene Therapy Group,
Dept. of Microbiology and Immunology,
College of Medicine
University of Arizona, USA

3/1994-7/1997    Postdoctoral Research Associate,
                                       Gene Therapy Program,
Arizona Cancer Center
University of Arizona, USA

9/1987-1/1994    Graduate Research Assistant,
Dept. of Radiation Oncology,
Dept. of Microbiology and Immunology,
Arizona Cancer Center
University of Arizona, USA

PATENTS:

US Patent 6,709,858   “Hyperthermic Inducible Expression Vectors for Gene Therapy and Methods of Use Thereof.” 2004.

US Patent 7,056,897   “Inducible Expression Vectors and Methods of Use Thereof.” 2006.

US Patent 7,285,542   “Hyperthermic Inducible Expression Vectors for Gene Therapy and Methods of Use Thereof.” 2007.

US Patent 8,158,126   “Stem Cell Fusion Model of Carcinogenesis”, Patents granted for US, China, and about 50 other countries.

EXTRAMURAL RESEARCH FUNDING:

“Cancer Immunotherapy by TCR-Modified HSC Transfer”
Principle InvestigatorArizona Biomedical Research Commission(ABRC)
Project Period: Sept. 1, 2005 – Aug. 31, 2008.
TOTAL COSTS: $150,000

“Bone Marrow Stem Cells in Injury Repair Response”
Co-Investigator
NIH/NINR P20
Center on Injury Mechanisms and Related Responses.
TOTAL COSTS: $20,000

“Genetic Influences of Exercise Adherence”
Co-Investigator
NIH/NINR P20
Center on Injury Mechanisms and Related Responses.
TOTAL COSTS: $20,000

“Combining Hyperthermia with Gene Therapy and Tumor Immunology”
Principle Investigator
Thermosurgery Technologies Inc.
             Project Period: Oct 1, 2003 – Sept 30, 2005.
TOTAL COSTS: $15,000

PUBLICATIONS: (peer-reviewed articles)

  1. Tsang, T.C., V. Copeland and G. T. Bowden. A Set of Cassette Cloning Vectors for Rapid and Versatile Adaptation of Restriction Fragments. BioTechniques 10: 330, 1991.
  2. Tsang, T.C. New Model for 70kDa Heat Shock Proteins’ Potential Mechanism of Function. Federation of European Biochemistry Society (FEBS) Letters 323:1-3, 1993.
  3. Tsang, T.C., Y-W Chu, M. B. Powell, J. Kittelson, L. Meade-Tollin, M. J. C. Hendrix and G. T. Bowden. V-jun Oncogene Suppresses Both Phorbol Ester Induced Cell Invasion and Stromelysin Gene Expression in a Mouse Papilloma Cell Line. Cancer Research 54:882-886, 1994.
  4. Tsang, T. C., D. T. Harris, E. T. Akporiaye, S. F. Schluter, G. T. Bowden and E. M. Hersh. A Simple Method for Adapting DNA Fragments and PCR Products to All of the Commonly Used Restriction Sites. BioTechniques 20:51-52, 1996.
  5. Tsang, T. C., D. T. Harris, E. T. Akporiaye, R. S. Chu, J. Brailey, F. Liu, F. H. Vasanwala, S. F. Schluter and E. M. Hersh. Mammalian Expression Vector with Two Multiple Cloning Sites for Expression of Two Foreign Genes. BioTechniques 22:68, 1997.
  6. Meade-Tollin, L.C., P. Boukamp, N. E. Fusenig, C. P. R. Bowen, T. C. Tsang and G.T. Bowden. Differential Expression of Matrix Metalloproteinases in Activated c-Harvey-ras-Transfected Immortalized Human Keratinocytes. British J. of Cancer 77:724-730, 1998.
  7. Tsang, T.C, F.H. Vasanwala and D.T. Harris. New Vectors for Very High Levels of Gene Expression, Inducible Gene Expression and Expression of Two Genes Simultaneously. Gene Therapy and Molecular Biology 2:462-470, 1998.
  8. Gerner, E.W., E.M. Hersh, M. Pennington, T.C. Tsang, D. Harris, F. Vasanwala and J. Brailey. Heat- inducible Vectors for Use in Gene Therapy. Int. J. Hyperthermia 16:171-181, 2000.
  9. Vasanwala, F.H., T.C. Tsang, A. Fellah, P. Yorgin and D.T. Harris. A Novel Expression Vector Induced by Heat, Gamma-Radiation and Chemotherapy. Gene Therapy and Molecular Biology 5:1-7, 2000.
  10. Tsang, T.C., J.L. Brailey, F.H. Vasanwala, R.S. Wu, F. Liu, P.R. Clark, L. Meade-Tollin, L. Luznick, A.T. Stopeck, E.T. Akporiaye and D.T. Harris. Construction of New Amplifier Expression Vectors for High Levels of IL-2 Gene Expression. Int. J. Molecular Medicine5:295-300, 2000.
  11. Zhang, T., T.C. Tsang and D.T. Harris. Comparison of Cis and Trans Tat Gene Expression in HIV LTR-Based Amplifier Vectors. BioTechniques 33:1146-51, 2002.
  12. Luo, P., T.C. Tsang, C.A. Takeuchi, J. Dekker, M. Badowski and D.T. Harris. High Efficiency Cloning Systems for Versatile Adaptation of DNA Fragments. BioTechniques 33:738-42, 2002.
  13. Zhang, T., T.C. Tsang and D.T. Harris. Efficient Transduction of Murine Primary T Cells Requires a Combination of High Viral Titer, Preferred Tropism, and Proper Timing of Transduction. J. Hematotherapy & Stem Cell Research 12:123-30, 2003.
  14. He, X., T.C. Tsang, P. Luo, T. Zhang and D.T. Harris. Enhanced Tumor Immunogenicity through Coupling Cytokine Expression with Antigen Presentation. Cancer Gene Therapy 10:669-677, 2003.
  15. Luo, P., X. He, T.C. Tsang and D.T. Harris. A Novel Inducible Amplifier Expression Vector for High and Controlled Gene Expression. Int. J. Molecular Medicine 13:319-325, 2004.
  16. Zhang, T., X. He, T.C. Tsang and D.T. Harris. SING: a novel strategy for identifying tumor-specific, cytotoxic T lymphocyte-recognized tumor antigens. The FASEB Journal 18:600-602, 2004.
  17. Zhang, T., X. He, T.C. Tsang and D.T. Harris. Transgenic TCR Expression: Comparison of Single Chain with Full-Length Receptor Constructs for T Cell Function. Cancer Gene Therapy 11:487- 496, 2004.
  18. He, X., F.H. Vasanwala, T.C. Tsang, P. Luo, T. Zhang and D.T. Harris. Decreased Tumor Growth using an IL-2 Amplifier Expression Vector. Gene Therapy and Molecular Biology 8:487-494, 2004.
  19. Pipes, B., F.H. Vasanwala, T.C. Tsang, T. Zhang, P. Luo and D.T. Harris. A Brief Heat Shock Increases Stable Integration of Lipid Mediated DNA Transfections. BioTechniques 38:48-52, 2005.
  20. He, X., T.C. Tsang, T. Zhang, P. Luo and D.T. Harris. Antigen Epitope-Expressing Cytokines for DNA Immunization. Vaccine 23:1966-72, 2005.
  21. He, X., V. Gonzalez, A.H. Tsang, J. Thompson, T.C. Tsang and D.T. Harris. Differential Gene Expression Profiling of CD34+ CD133+ Umbilical Cord Blood Hematopoietic Stem Progenitor Cells. Stem Cells and Development 14:188-198, 2005.
  22. He, X., P. Luo, T.C. Tsang, T. Zhang and D.T. Harris. Immuno-Gene Therapy of Melanoma by Tumor Antigen Epitope Modified IFN-gamma. Cancer Immunology Immunotherapy 54:741-9, 2005.
  23. He, X., T.C. Tsang, B.L. Pipes, R.J. Ablin and D.T. Harris. A Stem Cell Fusion Model of Carcinogenesis. J. Exp. Therapeutics and Oncology 5:101-109, 2005.
  24. Luo, P., T.C. Tsang, X. He, V. Gonzalez-Pena, M. Jaramillo, C. Takeuchi and D.T. Harris. Novel Amplifier Expression Vectors Producing Higher Levels of IL-2 Led to Slower Tumor Growth and Longer Survival in vivo. DNA Cell Biol 24:595-604, 2005.
  25. Pipes, B.L., T.C. Tsang, S-X Peng, M. Graham, R. Fiederlein and D.T. Harris. Telomere Length Changes After Umbilical Cord Blood Transplant. Transfusion 46:1038-1043, 2006.
  26. Dammeyer, P., M.C. Jaramillo, B.L. Pipes, M.S. Badowski, T.C. Tsang and D.T. Harris. Heat- inducible Amplifier Vector for High-level Expression of Granulocyte-Macrophage Colony Stimulating Factor. Int. J. Hyperthermia 22:407-419, 2006.
  27. Luo, P., T.C. Tsang, B. Reed, R.A. Flavell and D.T. Harris. A Self-Augmenting Gene Expression Cassette for Enhanced and Sustained Transgene Expression in the Presence of Pro-inflammatory Cytokines. DNA Cell Biol 25:659-667, 2006.
  28. Davis, A.H.T., J. Wang, T.C. Tsang and D.T. Harris. Direct Sequencing is More Accurate and Feasible in Detecting Single Nucleotide Polymorphisms than RFLP: Using Human Vascular Endothelial Growth Factor Gene as a Model. Biological Research for Nursing
  29. Badowski, M.S., T. Zhang, T.C. Tsang and D.T. Harris. Chimeric Antigen Receptors for Stem Cell. Based Immunotherapy. J. Exp. Therapeutics and Oncology 8:53-63, 2009.

  30. Li, H., Z. Feng, T.C. Tsang, T. Tang, X. Jia, X. He, M.E. Pennington, M.S. Badowski, A.K.M. Liu, D.Chen, D.T. Harris, J. Martinez, L.C. Meade-Tollin. Fusion of HepG2 Cells with Mesenchymal, Stem Cells Increases Cancer-associated and Malignant Properties: An in vivo Metastasis Model. Oncology Reports 32:539-547, 2014.